منابع مشابه
Multiple Sclerosis: Immunopathology and Treatment Update
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a medical challenge in MS to develop a treatment for progressive forms. The most common injectable disease-modifying therapies in RRMS include β-interferons 1a or 1b and glatiramer acetate. However, one of the major challenges of inje...
متن کاملThe Immunopathogenesis and Immunopathology of Systemic Lupus Erythematosus
P.H. Schur and E.M. Massarotti (eds.), Lupus Erythematosus: Clinical Evaluation and Treatment, DOI 10.1007/978-1-4614-1189-5_2, © Springer Science+Business Media New York 2012 Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by autoantibody production in association with systemic in fl ammatory manifestations that vary in pattern and severity. This disease occ...
متن کاملStatistical analysis of clinical and laboratory characteristics of systemic sclerosis
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and excessive collagen deposition in the skin and internal organs. Based on the skin damage we divide the patients into two groups: limited and diffuse SSc. In restricted type, the thickness of the skin is limited in the face and distal parts of the elbows and knees, with less involveme...
متن کامل[The arthropathy of systemic sclerosis].
Joint involvement occurs in thirds of SSc patients during the course of the disease, but may be the onset manifestation. Arthralgias, stiffness and tendon sheath involvement constitute the most common clinical findings affecting all joints, but predominantly the fingers, wrists and ankles. The most common radiographic abnormalities in SSc patients are subcutaneous calcinosis and digital tuft re...
متن کاملHigh frequency skin ultrasonography in systemic sclerosis
Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic...
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ژورنال
عنوان ژورنال: Seminars in Immunopathology
سال: 2015
ISSN: 1863-2297,1863-2300
DOI: 10.1007/s00281-015-0517-1